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Even for genetic causes of disease, working with iPSCs has its own set of challenges. iPSCs reprogrammed from the same parent fibroblast exhibit variability. Some of this variability likely reflects somatic mosaicism in the human tissue sample from which the.
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Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity.
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